Table 1. Characteristics of the subjects stratified by offspring of nonagenarian siblings and their partners.
| Offspring | Partners | |
| Characteristics | N = 250 | N = 250 |
| Demographics | ||
| Females, n (%) | 114 (45.6) | 139 (55.6) |
| Age, years | 66.3 (6.1) | 65.7 (7.2) |
| Years of education, median (IQR) | 12 (10–15) | 12 (10–15) |
| Anthropometrics | ||
| Height, cm | 172.5 (8.9) | 171.6 (8.8) |
| Weight, kg | 78.7 (13.4) | 79.2 (13.7) |
| Comorbidities*, n (%) | ||
| Diabetes mellitus | 7 (3.2) | 20 (9.1) |
| Myocardial infarction | 4 (1.8) | 8 (3.6) |
| Stroke | 5 (2.2) | 5 (2.3) |
| Hypertension | 56 (25.7) | 66 (30.6) |
| COPD | 13 (5.9) | 9 (4.1) |
| Malignancy | 13 (5.9) | 21 (9.6) |
| Rheumatoid arthritis | 2 (0.9) | 3 (1.4) |
| Intoxications, n (%) | ||
| Users of alcohol† | 192 (78.0) | 194 (78.5) |
| Former and/or current smokers | 158 (64.2) | 185 (74.9) |
| Inflammatory markers‡, median (IQR) | ||
| hsCRP, mg/L | 1.2 (0.65–2.49) | 1.4 (0.71–2.87) |
| IL-6, pg/mL | 0.30 (0.11–0.65) | 0.36 (0.13–0.62) |
| APOE genotype, n (%) | ||
| ε2ε2 | 2 (0.8) | 1 (0.4) |
| ε2ε3 | 27 (11.1) | 21 (8.4) |
| ε2ε4 | 11 (4.5) | 10 (4.0) |
| ε3ε3 | 151 (60.4) | 166 (66.7) |
| ε3ε4 | 51 (20.4) | 47 (18.9) |
| ε4ε4 | 2 (0.8) | 4 (1.6) |
Values are expressed as mean (standard deviation), unless otherwise indicated. Abbreviations: IQR, interquartile range; COPD, chronic obstructive pulmonary disease; hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin-6; APOE, apolipoprotein E.
*
n = 220 for offspring and n = 220 for partners.
†
Using ≥1 units per week.
‡
n = 240 for offspring and n = 240 for partners.