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Four naturally gemcitabine-resistant NSCLC cell lines (H125, H650, H1648, H2122) and four gemcitabine-resistant clones generated in vitro (H23-G-C8, H23-G-C23, H1299-G-C2, H1299-G-C18) were exposed to gemcitabine for 5 days. Data points are the mean of four replicates, and bars depict the standard error. There is a shift of the dose-response curve to the left in addition to an increase in the maximally achievable cytotoxicity.
