Figure 6. Inhibition of TLR2 or MyD88 activity inhibits repair. CD44+/MyD88+ EOC stem cells were transfected with a dominant-negative form of TLR2 or a dominant-negative form MyD88 prior to wounding. The effect of blocking TLR2 or MyD88 function on repair is then determined. Note the significant decrease on wound repair in cells transfected with TLR2 or MyD88 dominant-negative plasmids. TLR2-dn, TLR2-dominant-negative; MyD88-dn, MyD88-dominant-negative. *p < 0.005.