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. 2013 Feb 28;19(8):1210–1218. doi: 10.3748/wjg.v19.i8.1210

Figure 6.

Figure 6

Effects of mitogen-activated protein kinases inhibitors on prostaglandin E2-induced action in interstitial cells of Cajal. A: Pacemaker currents of interstitial cells of Cajal (ICCs) treated with 5 μmol/L prostaglandin E2 (PGE2) at a holding potential of -70 mV; B: Pacemaker currents after pretreatment with PD 98059 (10 μmol/L) prior to PGE2 treatment; C: Pacemaker currents after pretreatment with SB 203580 (10 μmol/L) prior to PGE2 treatment. The effects of mitogen-activated protein kinases inhibitors on the PGE2-induced action are summarized in D and E. Bars represent mean ± SE values (n = 4 per group). aP < 0.05 vs PGE2. Con: Control, PD: PD 98059, SB: SB203580.