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In vivo degradation of PC-crosslinked ECM three weeks after subcutaneous implantation in SD rats. Inflammatory cells and native fibroblasts penetrated in the non-crosslinked (A) and GA-crosslinked (B) ECMs. By contrast, they stayed close to surface (C) and not in the inner part of ECM (D) of 0.1 mg/ml PC- crosslinked ECMs. Arrows indicate inflammatory congregated at the ECM surface. Scale bars in A and C is 50 μm, in B and D 20 μm
