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. 2011 Sep;23(3):218–223. doi: 10.1007/s11670-011-0218-9

Figure 2.

Figure 2

Dose-dependent prevention effect of pretreated curcumin on mdr1 mRNA expression induced by ADM in K562 cells. Cells were pretreated with 1 μmol/L, 5 μmol/L curcumin or 5 μmol/L CsA (combined group) or 0.5% DMSO (control and ADM alone groups) for 24 h and then were co-incubated with 40 ng/ml ADM for 48 h (combined group and ADM alone group). After the above procedures, cells in 5 groups were then determined for mdr1 mRNA expression by RT-PCR. Data are shown as x̄±s of three independent experiments. *Significantly different from the ADM alone group (P<0.05).