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. 2013 Mar 4;8(3):e57423. doi: 10.1371/journal.pone.0057423

Figure 5. Drug response of MCF-7 WT cells and MCF-7 DOX cells to 20 µM doxorubicin during 24 h at LF (10 kHz).

Figure 5

Data points (mean ± SEM, n = 5) were normalized to the magnitude value at t = 0 h. The impedance drops sharply at LF for MCF-7 WT cells, indicating that 20 µM doxorubicin is strong enough to induce toxic effects, while cells in the absence of drug (control) were healthy and LF signal was relatively unchanged. On the other hand, MCF-7 DOX cells displayed increasing impedance compared to their control indicating resistance to this drug concentration and demonstrating the substantial differences in the drug response of MCF-7 WT cells and their drug resistant phenotypes.