Table 1.

Reported effects of scopolamine on PPI and startle reaction in mice and rats.

	Strain	Scopolamine Dose	Control Treatment	PPI	Startle	References
Rats	Wistar	0.33 mg/kg	Saline	↓	≈	Hohnadel et al. 2007
		0.14 and 1 mg/kg	Saline	↓	?	Tadros et al. 2009
		1 mg/kg	Saline	↓	↓	Yeomans et al. 2010
	Sprague Dawley	1 mg/kg	Saline	↓	≈	Wu et al. 1993
		0–40 nmol/0.5µl*	Saline	↓	≈	Fendt and Koch, 1999
		0.3–1.0 mg/kg	Saline	↓	≈	Jones and Shannon, 2000a
		0.3–1.0 mg/kg	Saline mSCP	↓	≈	Jones and Shannon, 2000b
		0.1 mg/kg	Saline mSCP	↓	≈	Stanhope et al. 2001
		0.3 and 0.56 mg/kg	Saline	↓	↑	Sipos et al. 2001
		0.5 mg/kg	Saline	↓	≈	Jones et al. 2005
		0.3 mg/kg	Saline	↓	≈	Andrus et al. 2007
		0.4 mg/kg	Saline	↓	≈	Mitchell and Neumaier, 2008
Mice	C57BL/6	3, 10 and 30 mg/kg	Saline	≈	≈	Ouagazzal et al. 2001
		1 mg/kg	Saline	↓	?	Yeomans et al. 2010
	C57BL/6NTac	1, 1.8 mg/kg	Saline	↓	↑	Thomsen et al., 2010
	ddY	0.3 mg/kg	Saline	≈	↑	Ukai et al. 2004
	Swiss	0.3 mg/kg	Saline	≈	↑	Eleore et al. 2007

↑: PPI/startle enhanced, ↓: PPI/startle reduced, “≈” PPI/startle unaltered, “n/a” data not available.

^*bilateral microinfusion in caudal pontine reticular nucleus. “mSCP” refers to methyl-scopolamine.