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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Health Serv Outcomes Res Methodol. 2012 Oct 5;12(4):288–301. doi: 10.1007/s10742-012-0101-2

Table 2.

Simulation results for as valid instrument (true effect=3)

Method* Estimate Abs. Rel. Bias Std. Error
U2 is not associated with A1 or A2. R-IV 16.60 443% 727.30
S-IV 4.68 56% 2.63
M-IV 3.86 29% 2.44
Regression 3.35 12% 0.40
U2 is only associated with A2. Moderate Association R-IV −66.24 2308% 2115
S-IV 4.31 44% 2.48
M-IV 3.58 19% 2.26
Regression 3.92 31% 0.36
Strong association R-IV 4.20 40% 284.10
S-IV 4.71 57% 2.78
M-IV 3.73 24% 2.47
Regression 4.53 51% 0.38
Very strong association R-IV 42.23 1308% 940.69
S-IV 4.81 60% 3.63
M-IV 3.56 19% 3.77
Regression 6.26 109% 0.35
*

: R-IV for using randomization as the instrument, S-IV for using self-selection as the instrument, M-IV for matching enhanced IV estimation, and Regression for using the conventional linear regression model.