. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Eur J Med Chem. 2012 Dec 5;60:456–468. doi: 10.1016/j.ejmech.2012.11.041

Table 1.

Relative hTK1 phosphorylation rates (rPRs) of N3-substituted dThd analogues

Compounds	rPR (%) ± SD¹	Compounds	rPR (%) ± SD¹
dThd	100	7f	15.5 ± 1.9
N5-2OH	46.3 ± 14.0	7g	27.3 ± 3.0
3a	1.9 ± 0.5	8	39.5 ± 3.6
3b	2.3 ± 0.4	9a	55.7 ± 5.2
3c	11.3 ± 0.9	9b1/2	52.4 ± 5.8
3d	16.8 ± 0.8	9c1/2	58.2 ± 1.2
3e	3.0 ± 0.2	9d1/2	63.7 ± 3.4
3f	5.6 ± 0.5	10	0.0 ± 0.0
7a	0.0 ± 0.0	11a	57.6 ± 8.5
7b	1.2 ± 0.9	11b1/2	55.6 ± 3.2
7c	1.9 ± 1.3	11c1/2	42.9 ± 5.1
7d	14.9 ± 2.1	11d1/2	42.5 ± 5.8
7e	16.3 ± 1.0

Data represent the means of three replicates ± SD.