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. Author manuscript; available in PMC: 2013 Mar 5.
Published in final edited form as: Gastroenterology. 2010 Apr 29;139(2):598–608. doi: 10.1053/j.gastro.2010.04.046

Figure 5. Effect of inhibition of caspase-3 on triptolide response in pancreatic cancer cells.

Figure 5

Knockdown of caspase-3 by siRNA pool for 24 h followed by 200 nM triptolide treatment for 24 h decreases capase-3 activation in MiaPaCa-2, S2-013 and S2-VP10 cells when compared to cells treated with lipofectamine alone (control) or non-silencing siRNA (NS) and 200 nM triptolide (A). The viability of MiaPaCa-2 but not S2-013 and S2-VP10 cells is significantly rescued after the knock-down of caspase-3 followed by triptolide treatment when compared with control or NS cells treated with triptolide (B). The bars represent mean ± SEM, n=3, **p <0.01 (t test), ## p< 0.01 (t test).