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. Author manuscript; available in PMC: 2013 Mar 5.
Published in final edited form as: Exp Clin Psychopharmacol. 2012 Aug 6;20(5):352–363. doi: 10.1037/a0029135

Figure 1.

Figure 1

Diagram of experimental groups (1, 2, 3) and the sequence of training/testing phases in each experiment. In Experiment 1, note that mice which were assigned the highest cocaine dose (1.0 mg/kg/infusion) proceeded directly from reacquisition to the PR training. Mice assigned to lower doses were first required to meet baseline, extinction, and rebaseline criteria at the 1.0 mg/kg/infusion dose (to provide a similar starting point for all mice). Regardless of dose, mice which failed to acquire cocaine self-administration were similarly required to meet criteria at the 1.0 mg/kg/infusion dose before proceeding to the PR training. Some attrition due to catheter failure or health complications occurred throughout experimental phases.