Table 1.
Reinforcers Earned at Criteria for Acquisition, Extinction, and Reacquisition
Reinforcer/phase | WT | D3+/− | D3−/− |
---|---|---|---|
Cocaine 0.32 mg/kg/infusion | (N = 6) |
(N = 1) |
(N = 1) |
Acquisition | 56.5 ± 9.8* | 58.0n/a | 47.8n/a |
Extinction | 13.0 ± 2.6 | 24 | 22 |
Reacquisition | 58.4 ± 16.2* | 50n/a | 54n/a |
Cocaine 1.0 mg/kg/infusion | (N = 8) | (N = 4) |
(N = 4) |
Acquisition | 23.9 ± 1.2*** | 23.7 ± 1.8*** | 23.1 ± 1.4** |
Extinction | 8.3 ± 2.5 | 6.3 ± 0.9 | 7.3 ± 2.7 |
Reacquisition | 22.8 ± 1.8*** | 25.7 ± 2.1*** | 24.8 ± 3.0** |
Liquid food | (N = 14) |
(N = 10) |
(N = 11) |
Acquisition | 69.9 ± 2.9*** | 70.5 ± 5.0*** | 61.3 ± 3.9*** |
Extinction | 20.0 ± 1.9 | 21.4 ± 2.6 | 21.5 ± 2.8 |
Reacquisition | 65.4 ± 4.7*** | 63.2 ± 7.3*** | 68.3 ± 4.6*** |
Note. In mice that met acquisition criteria, there was no significant effect of D3 genotype on the number of reinforcers earned at criteria for acquisition, extinction, or reacquisition.
p < .05.
p < .01.
p < .001 vs. extinction (Tukey's test).
Statistical analysis not applicable.