. Author manuscript; available in PMC: 2013 Mar 5.

Published in final edited form as: Exp Clin Psychopharmacol. 2012 Aug 6;20(5):352–363. doi: 10.1037/a0029135

Table 1.

Reinforcers Earned at Criteria for Acquisition, Extinction, and Reacquisition

Reinforcer/phase	WT	D₃^+/−	D₃^−/−
Cocaine 0.32 mg/kg/infusion	(N = 6)	(N = 1)	(N = 1)
Acquisition	56.5 ± 9.8^*	58.0^n/a	47.8^n/a
Extinction	13.0 ± 2.6	24	22
Reacquisition	58.4 ± 16.2^*	50^n/a	54^n/a

Cocaine 1.0 mg/kg/infusion	(N = 8)	(N = 4)	(N = 4)
Acquisition	23.9 ± 1.2^***	23.7 ± 1.8^***	23.1 ± 1.4^**
Extinction	8.3 ± 2.5	6.3 ± 0.9	7.3 ± 2.7
Reacquisition	22.8 ± 1.8^***	25.7 ± 2.1^***	24.8 ± 3.0^**

Liquid food	(N = 14)	(N = 10)	(N = 11)
Acquisition	69.9 ± 2.9^***	70.5 ± 5.0^***	61.3 ± 3.9^***
Extinction	20.0 ± 1.9	21.4 ± 2.6	21.5 ± 2.8
Reacquisition	65.4 ± 4.7^***	63.2 ± 7.3^***	68.3 ± 4.6^***

Note. In mice that met acquisition criteria, there was no significant effect of D₃ genotype on the number of reinforcers earned at criteria for acquisition, extinction, or reacquisition.

p < .05.

^**

p < .01.

^***

p < .001 vs. extinction (Tukey's test).

^n/a

Statistical analysis not applicable.