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Both common carotid arteries (BCCA) occlusion-induced increase of ISG15 expression in the hippocampus. Immunohistochemistry showing strong expression of ISG15 (A), GFAP (B), and Iba-1 (C) in the hippocampus of mice subjected to BCCA occlusion but not sham controls (D, E, F). Double-staining showing the co-localization of ISG15 (G) with GFAP-positive cells (H) in the hippocampus. (I): overlap of (G) and (H).
