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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Curr Opin Neurobiol. 2012 Jun 19;22(5):785–790. doi: 10.1016/j.conb.2012.04.004

Figure 1.

Figure 1

Phenotypes demonstrated by human iPSC-derived RTT neurons. We generated a human cellular model for RTT by reprogramming the fibroblasts of human patients to iPSCs. Neurons differentiated from these iPSCs exhibited cellular phenotypes such as (a) smaller soma size, (b) reduced dendritic branching, and (c) fewer glutamatergic synapses and (d) dendritic spines. These morphological alterations contributed to the functional phenotype of (e) altered electrophysiology, as RTT-neurons demonstrated a decreased frequency of spontaneous postsynaptic currents.