Figure 5.

Ischemic animals showed long-term improvement of neurological function after glibenclamide (Gbc) treatment. Contralateral forelimb use (cylinder test) (A) and limb-placing scores (B) during a 30-day follow-up after middle cerebral artery occlusion (MCAO). Swimming strategy in the probe trial test (Morris water-maze) on post-operative day 28 (C, D). Here the values are shown as a percentage of time spent in equal zones of the pool. Zone 1 refers to the inner annulus and zone 3 the outermost annulus. Results are mean±s.e.m. (n=9–12). *P<0.05; **P<0.01 (compared with sham-operated rats); ^#P<0.05; ^##P<0.01 (compared with vehicle-treated MCAO rats).