Figure 6.

Angiopoietin-2 (Ang2) fails to influence mRNA expression of blood–brain barrier (BBB) proteins but counteracts vascular endothelial growth factor (VEGF)-induced decrease in their expression. mRNA were extracted from the ischemic cortices 3 hours after middle cerebral artery occlusion (MCAO) and the expression of claudin5 and VE-cadherin mRNA was evaluated. Mean±s.d., n=3 mice/group, *P<0.05 versus control, ^$P<0.05 versus VEGF, Fisher protected least significant difference (PLSD) following a significant analysis of variance.