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. 2012 Dec 5;33(3):407–414. doi: 10.1038/jcbfm.2012.180

Table 3. Kinetic rate constants estimated with a 2-TCMi (irreversible trapping compartment) with 60 and 90 minutes of scan data.

  60 minutes of data
 90 minutes of data
  K1 k2 k3 λk3 Ki K1 k2 k3 λk3 Ki CBF
  mL per cm3 per minute 1/min 1/min mL per cm3 per minute mL per cm3 per minute mL per cm3 per minute 1/min 1/min mL per cm3 per minute mL per cm3 per minute mL per minute per 100 mL
Insular cortex 0.27±0.04 (3.1±0.4) 0.11±0.01 (8.8±1.4) 0.059±0.008 (7.6±1.1) 0.150±0.021 (3.2±0.4) 0.096±0.013 (2.2±0.2) 0.27±0.04 (3.0±0.4) 0.10±0.01 (8.3±1.5) 0.053±0.007 (6.9±1.2) 0.145±0.020 (2.9±0.5) 0.094±0.012 (1.8±0.2) 68±15
Occipital cortex 0.28±0.05 (2.7±0.3) 0.11±0.01 (7.3±0.9) 0.055±0.007 (6.4±0.8) 0.138±0.022 (2.8±0.3) 0.091±0.014 (1.7±0.3) 0.27±0.05 (2.7±0.3) 0.10±0.01 (7.0±1.0) 0.051±0.007 (5.9±0.8) 0.133±0.022 (2.5±0.4) 0.088±0.014 (1.4±0.3) 60±29
Cerebellar cortex 0.26±0.03 (2.4±0.3) 0.10±0.01 (7.0±1.2) 0.057±0.010 (6.2±1.0) 0.157±0.029 (2.6±0.5) 0.098±0.015 (1.7±0.4) 0.26±0.03 (2.3±0.3) 0.09±0.01 (6.7±1.2) 0.052±0.009 (5.6±0.9) 0.151±0.028 (2.4±0.4) 0.096±0.014 (1.4±0.3) 57±15
Temporal cortex 0.29±0.05 (2.7±0.6) 0.11±0.02 (7.3±1.5) 0.057±0.007 (6.4±1.1) 0.151±0.026 (2.7±0.5) 0.098±0.015 (1.7±0.4) 0.28±0.05 (2.6±0.5) 0.10±0.02 (7.0±1.2) 0.052±0.007 (5.8±0.9) 0.145±0.026 (2.5±0.4) 0.095±0.015 (1.4±0.3) 68±19
Prefrontal cortex 0.28±0.05 (2.5±0.6) 0.11±0.01 (6.8±1.7) 0.054±0.006 (6.0±1.4) 0.135±0.026 (2.6±0.6) 0.090±0.015 (1.8±0.4) 0.27±0.05 (2.5±0.5) 0.10±0.01 (6.4±1.4) 0.049±0.006 (5.5±1.1) 0.130±0.026 (2.4±0.5) 0.087±0.015 (1.5±0.3) 75±24
Caudate 0.26±0.04 (3.6±0.9) 0.09±0.02 (10.3±3.2) 0.049±0.007 (9.7±3.1) 0.141±0.022 (4.3±1.2) 0.092±0.012 (2.8±0.7) 0.26±0.03 (3.4±0.7) 0.09±0.01 (9.5±2.3) 0.044±0.007 (8.5±2.0) 0.135±0.022 (3.7±0.8) 0.089±0.011 (2.4±0.4) 61±14
Putamen 0.31±0.06 (2.6±0.7) 0.10±0.02 (7.1±2.5) 0.049±0.007 (6.7±2.2) 0.155±0.027 (3.0±0.8) 0.102±0.016 (2.1±0.5) 0.30±0.05 (2.4±0.6) 0.09±0.02 (6.5±2.0) 0.046±0.007 (5.7±1.5) 0.150±0.027 (2.5±0.6) 0.100±0.016 (1.6±0.3) 52±12
Thalamus 0.28±0.04 (3.5±0.7) 0.09±0.01 (10.4±2.7) 0.056±0.007 (9.3±2.2) 0.168±0.027 (3.9±0.9) 0.105±0.013 (2.7±0.5) 0.28±0.04 (3.3±0.6) 0.08±0.01 (9.7±2.4) 0.049±0.006 (8.3±2.0) 0.161±0.026 (3.5±0.8) 0.101±0.013 (2.2±0.5) 59±12
Ant. cingulate cortex 0.25±0.05 (3.3±0.4) 0.10±0.02 (9.4±1.2) 0.057±0.012 (8.2±0.9) 0.138±0.022 (3.5±0.4) 0.087±0.012 (2.2±0.5) 0.24±0.05 (3.3±0.4) 0.09±0.02 (9.2±1.5) 0.052±0.010 (7.7±1.1) 0.132±0.021 (3.2±0.3) 0.085±0.012 (1.9±0.2) 82±21
Average 0.275 (2.9) 0.101 (8.3) 0.055 (7.4) 0.148 (3.2) 0.096 (2.1) 0.271 (2.8) 0.094 (7.8) 0.050 (6.6) 0.142 (2.8) 0.093 (1.7)  

CBF, cerebral blood flow; TCM, tissue compartment model.

Between parentheses are coefficients of variation estimated from the diagonal of the covariance matrix of the fitting. Data are represented as mean±s.d. (n=6).