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. 2012 Dec 5;33(3):372–380. doi: 10.1038/jcbfm.2012.184

Figure 3.

Figure 3

Changes in apparent diffusion coefficient (ADC) for acute mountain sickness (AMS) and no-AMS groups across all cerebral regions. (A) Change in ADC between 2 days hypoxia and normoxia (2d-N) (at this time point, AMS subjects are symptomatic and no-AMS subjects are asymptomatic), (B) between 7 days hypoxia and normoxia (7d-N) (at this time point, all subjects are asymptomatic), (C) between 2 days and 7 days hypoxia (7d-2d) (shows changes occurring during hypoxia acclimatization period). The no-AMS group is characterized by increased ADC on both days (A, B), and little change in ADC during hypoxia acclimatization period. AMS group are characterized by reduced ADC at 2 days when symptomatic, and increased ADC at 7 days when asymptomatic. Large increase in ADC during hypoxia acclimatization period as symptoms abate. Data are mean changes. Error bar=1s.d. Significant differences in ADC between 2 days hypoxia and normoxia (P<0.05, main effect of AMS). At 7 days hypoxia, no significant differences in relative ADC (P=NS, main effect of AMS). During acclimatization period (2 days to 7 days hypoxia) changes in ADC were significant between groups (P<0.05, main effect of AMS).