Figure 7.

Voxel-wise changes in apparent diffusion coefficient (ADC), showing voxels with a signal change corresponding to symptoms of acute mountain sickness (AMS). Color scale indicates ADC change between symptomatic (AMS group) and asymptomatic (no-AMS group) evaluated as the difference between ADC at 2 days hypoxia (when AMS subjects are symptomatic, no-AMS subject are asymptomatic) and 7 days hypoxia (when all subject are asymptomatic). Voxels with ADC change <10 × 10⁻⁶ s/mm² (i.e., insignificant difference between AMS and no-AMS group) or ADC change >100 × 10⁻⁶ s/mm² (i.e., artifactually large changes, likely because of misregistration subtraction errors) are not colored. Map indicates that basal ganglia, frontal gray matter, and regions of parietal and temporal cortex, as well as scattered areas of white matter in centrum semiovale show ADC changes that increase with AMS symptoms. The color reproduction of this figure is available at the Journal of Cerebral Blood Flow and Metabolism journal online.