Figure 5.

An additional cerebral microinfarct (CMI) identified with histology. A CMI in a formalin-fixed coronal brain slice of a 79-year-old patient with Alzheimer's disease (AD) pathology. The CMI is presented as a hyperintense cortical lesion on an ultra-high resolution fluid attenuated inversion recovery (FLAIR) (A; arrow; 400 × 400 × 400 μm³) and an ultra-high resolution T₂ weighted (B; arrow; 400 × 400 × 400 μm³) magnetic resonance (MR) image. On histopathologic examination, this cortical lesion was established as a CMI (C, Luxol fast blue & Periodic acid-Schiff (L&P) stain, and in greater detail D, L&P stain). Note the smaller CMI in (C) and (D) (open arrow) which was initially solely identified on histopathologic examination, but at reinspection proved to be visible on the ultra-high resolution T₂ weighted MR image as well (B; open arrow).