Table 3.
Studies evaluating the prognostic value of metabolic tumor volume in head and neck squamous cell carcinoma.
| Study (year) | Number of patients | Type of study | Conclusion | Ref. |
|---|---|---|---|---|
| Dibble et al. (2012) | 45 | Retrospective | Primary tumor MTV and TGA are potential FDG markers for time to survival in patients with oral and oropharyngeal SCC and may provide prognostic information in addition to the AJCC stage | [15] |
| Chung et al. | 82 | Retrospective | MTV >40 ml indicated a significantly worse DFS than MTV <40 ml (HR: 3.42; 95% CI: 1.04–11.26; p = 0.04). MTV has a potential value in predicting short-term outcome and DFS in patients with pharyngeal cancers | [60] |
| Romessor et al. (2012) | 41 | Retrospective | GTV and MTV demonstrate superior prognostic utility as compared with SUVmax′, with larger tumor volumes correlating with inferior LC (p = 0.001) and OS (p = 0.04) in HNSCC patients treated with definitive IMRT | [61] |
| Tang et al. (2012) | 83 | Retrospective | Total MTV of 17 cm was associated with a 2.1-fold increase in the risk of disease progression (p = 0.0002) and a twofold increase in the risk of death (p = 0.0048). SUVmax was not associated with either outcome MTV independently predicts outcomes in HNSCC | [66] |
| Chu et al. (2012) | 51 | Retrospective | Primary tumor MTV velocity predicted disease progression (HR: 2.94; p = 0.01) and OS (HR: 1.85; p = 0.03). Primary tumor MTV velocity appears to be a better prognostic indicator of disease progression and survival in comparison to nodal MTV velocity | [67] |
| Murphy et al. (2011) | 47 | Retrospective | Postradiation MTV is an adverse prognostic factor in HNSCC. MTV of 21 ml (calculated by fixed SUVmax of 2.0) was associated with an increased risk of disease progression (HR: 2.5; p = 0.0001) and death (HR: 2.0; p = 0.003) | [16] |
AJCC: American Joint Committee on Cancer; DFS: Disease-free survival; FDG: 18F-fluoro-2-deoxyglucose; GTV: Gross tumor volume; HNSCC: Head and neck squamous cell carcinoma; HR: Hazard ratio; LC: Local control; IMRT: Intensity modulated radiation therapy; MTV: Metabolic tumor volume; OS: Overall survival; SCC: Squamous cell carcinoma; SUVmax: Maximum standardized uptake value; TGA: Total glycolytic activity.