Table 2.
RCYs of [18F]fluoroarenes from the NCA radiofluorination of unsymmetrical diaryl sulfoxides in DMF.
 | |||||
|---|---|---|---|---|---|
| Entry | Substratea | Conditionsb |
RCY (%)c |
||
| Temp (°C) |
Time (s)d |
Ar18F | Ar’18F | ||
| 1 | 13 | 130 | 224 | 1a, 64 (56) | 10a 0 (0) |
| 2 | 14 | 120 | 236 | 1a, 93 (89) | 2a, <1 (<1) |
| 3 | 15 | 150 | 314 | 1a, 76 (68) | 4a, 0 (0) |
| 4 | 16 | 200 | 236 | 16a, 73 (55) | 10a 0 (0) |
| 5 | 17 | 140 | 314 | 17a, 46 (32) | 1a, 43 (25) |
| 6 | 18 | 200 | 236 | 18a, 61 (43) | 10a 0 (0) |
| 7 | 19 | 140 | 236 | 19a, 36 (20) | 1a, 45 (35) |
| 8 | 20 | 200 | 236 | 20a 0 (0) | 10a 0 (0) |
a
5 mM in DMF.
b
Conditions giving highest RCYs among 8−12 different runs, except for entry 8 where the most extreme tested condition is given.
c
RCYs are those determined with HPLC. RCYs given in parentheses are with correction for radioactivity adsorption in the apparatus.
d
Estimated residence time in the micro-reactor.