Figure 2.

Mitochondria defects in Neurodegenerative Disease: (A) Mitochondria are organelles implicated in energy production and endogenous ROS production. They are responsible for more than 90% of the ROS production in the cell. The five proteins of electron transport chain are located in the inner membrane. (B) Mitochondrial impairment causes an excessive quantity of ROS/RNS, inducing oxidative stress. The latter is the most frequent event associated with neuronal loss in neurodegenerative diseases.