Table 3.

Genes encoding epigenetic chromatin modification enzymes downregulated in normal karyotype B cell pediatric ALL compared with normal controls.

	Gene	Description	NBM	ALL	Change	p value
1	HDAC5	Histone deacetylase 5	11379.83	186.94	0.01	2.67 × 10−27
2	NOTCH2	Notch homolog 2	32473.8	319.09	0.01	3.05 × 10−27
3	NOTCH1	Notch homolog 1	13109.41	1089.23	0.05	9.19 × 10−15
4	EP300	E1A binding protein p300	47487.19	5601.60	0.12	1.37 × 10−13
5	PRMT2	Protein arginine methyltransferase 2	28388.11	6336.82	0.22	2.08 × 10−12
6	DNMT3A	DNA (cytosine) methyltransferase 3 alpha	3868.084	682.15	0.17	2.04 × 10−12
7	RPS6KA3	Ribosomal protein S6 polypeptide 3	20389.11	5203.03	0.25	1.00 × 10−5

NBM, Normal Bone Marrow.