Table 18.
Pharmacokinetic parameters of TA-III after intragastrical administration to rats at a dose of 75 mg/kg.
| Parameters | Rat1 | Rat 2 | Rat 3 | Rat 4 | Rat 5 | MEAN ± SD |
|---|---|---|---|---|---|---|
| T (peak)(h) | 8 | 10 | 8 | 8 | 8 | 8.4 ± 0.9 |
| C (max)(ng/mL) | 546.1 | 305 | 363 | 607.3 | 583.3 | 480.9 ± 137.4 |
| Ke (1/h) | 0.386 | 0.088 | 0.313 | 0.364 | 0.548 | 0.340 ± 0.166 |
| Ka (1/h) | 0.567 | 0.332 | 0.496 | 0.571 | 0.7 | 0.533 ± 0.134 |
| t1/2 (ka)(h) | 1.222 | 2.088 | 1.396 | 1.213 | 0.991 | 1.382 ± 0.420 |
| t1/2 (h) | 1.794 | 7.908 | 2.216 | 1.902 | 1.264 | 3.017 ± 2.756 |
| MRT (0–∞)(h) | 14.236 | 17.46 | 19.741 | 12.753 | 16.889 | 16.216 ± 2.754 |
| AUC (0–∞)[(ng/mL)h] | 2938.3 | 4081.9 | 1992.8 | 3432.8 | 2424.3 | 2974.07 ± 822.2 |