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FGF1 multiprotein release complex (MRC): a hypothetical scheme. The copper-dependent MRC comprises a dimer of FGF1, sphingosine kinase 1 (SphK1), p40 synaptotagmin 1, S100A13 and annexin 2 (Anx 2). The assembly of MRC takes place at the inner plasma membrane leaflet of stressed cells. The externalization of MRC components depends on transmembrane translocation of acidic phospholipids.
