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The oncofetal H19 RNA connection: hypoxia, P53 and cancer. (A) Under hypoxic conditions, HIF1-α upregulates H19 RNA expression in p53 mutant cells. H19 induction under hypoxic stress thus contributes to various aspects of tumor progression, including survival, angiogenesis, metastasis and also multidrug resistance; (B) P53 wild-type suppresses H19 RNA upregulation by HIF1-α, probably leading to cell death.
