Figure 7.

Signatures of Mutational Processes Extracted from the Mutational Catalogs of 100 Breast Cancer Exomes

(A) Two mutational signatures deciphered from the base substitutions (including their immediate 3′ and 5′ sequence context) identified in the exomes of 100 breast cancers.

(B) Strand bias signatures deciphered from the base substitutions identified in the exomes of 100 breast cancers.

(C) Sequence context independent summary of strand bias in the two mutational signatures extracted from the 100 breast cancer exomes.

The error bars represent the SD of the contributions for each mutation type for the deciphered signature.