Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A proposed pathway scheme of ginsenoside Rh2 on LPS-primed RAW 264.7 murine macrophages. Ginsenoside Rh2 inhibits upstream signal TLR4/CD14 expressions and regulates TAK1 phosphorylation, eventually blocking NF-κB activation. Meanwhile, ginsenoside Rh2 suppressed LPS-induced HIF-1α accumulation at least partially dependent on NF-κB activation. This study indicates that ginsenoside Rh2 effectively modulates the regulation of NF-κB via TAK1 in RAW 264.7 murine macrophages.
