Table 1.
Passive and active electrical properties of intact dorsal root ganglia neurons from control, near-normoglycemic, and hyperglycemic, groups. Data are illustrated as mean ± S.E.M (n), where the value in parenthesis indicates the number of neurons.
| Parameter | Control | Near-normoglycemic | Hyperglycemic |
|---|---|---|---|
| Resting potential (mV) | −58.3 ± 1.7 (11) | −60.2 ± 1.0 (16) | −54.0 ± 1.4a (11) |
| Input resistance (MΩ) | 14.9 ± 2.2 (10) | 13.8 ± 2.1 (16) | 12.3 ± 1.5 (10) |
| Limiar current (pA) | 1909.1 ± 315.2 (11) | 1668.8 ± 147.1 (16) | 1618.2 ± 202.2 (11) |
| AP amplitude (mV) | 72.7 ± 3.6 (11) | 73.5 ± 3.2 (16) | 66.1 ± 3.9 (11) |
| AP duration (ms) | 0.9 ± 0.1 (11) | 0.9 ± 0.1 (16) | 2.0 ± 0.3a (11) |
| Maximum ascendant inclination (V/s) | 195.5 ± 28.9 (11) | 191.2 ± 19.1 (16) | 110.9 ± 15.3a (11) |
| Maximum descendant inclination (V/s) | 124.5 ± 15.0 (11) | 115.6 ± 10.8 (16) | 75.5 ± 9.2a (11) |
AP: action potential; aindicates statistical difference compared to control group (P < 0.05, ANOVA followed by Student-Newman-Keuls comparisons test for resting potential and maximum ascendant inclination and P < 0.05, ANOVA on ranks followed by Dunn's comparisons test for AP duration and maximum descendant inclination).