Table 2.

Kinetic properties of recombinantly expressed CYP2B6 protein variants with bupropion and efavirenz.

Variant	System	Bupropion hydroxylation			Efavirenz 8-hydroxylation			Reference
		Km(μM)	Vmax (%)	CLint (%)	Km(μM)	Vmax (%)	CLint (%)
2B6.1	COS-1	87	100	100	2.07	100	100	Radloff et al. (2013)
	E. coli	95	100	100	7.3	100	100	Zhang et al. (2011b)
	Sf9				7.7	100	100	Ariyoshi et al. (2011)
	Sf9	64	100	100	3.2	100	100	Xu et al. (2012)
2B6.6	COS-1	72	81	98	1.21	107	183	Radloff et al. (2013)
	E. coli	380	175	43	198	563	20	Zhang et al. (2011b)
	Sf9				12.4	81	50	Ariyoshi et al. (2011)
	Sf9	63	139	143	8.8	133	49	Xu et al. (2012)
2B6.4	E. coli	162	60	35	5.5	73	96	Zhang et al. (2011b)
	Sf9				9.16	169	142	Ariyoshi et al. (2011)
2B6.5	COS-1	65	44	59	1.15	46	83	Radloff et al. (2013)
	E. coli	134	66	47	53	1005	138	Zhang et al. (2011b)

Only studies which determined kinetic parameters (K_m, V_max, or K_cat) were included.