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. 2013 Feb 5;9:644. doi: 10.1038/msb.2012.69

Table 1. Improved chain convergence using Hessian-guided MCMC searches.

  Fraction of parameters that convergeda
MCMC stepsb 1 150 000 1 000 000 750 000 500 000 100 000 50 000
Hessian guidedc 78/78 77/78 73/78 70/78 40/78 21/78
Non-guidedd 65/78 62/78 55/78 50/78 24/78 12/78

aAverage number of parameters for which convergence was achieved for a series of 10 MCMC walks after the indicated number of steps.

bNumber of MCMC steps in a chain.

cMCMC chains guided by the Hessian.

dMCMC chains not guided by the Hessian.