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. 2013 Mar;182(3):1021–1030. doi: 10.1016/j.ajpath.2012.11.022

Figure 6.

Figure 6

AICAR activates AMPK-ACC pathways in HPAECs. A: Dose-dependent phosphorylation of AMPK by AICAR. HPAECs were stimulated with AICAR at 0.1 to 2 mmol/L for 1 hour. B: Time-dependent phosphorylation of AMPK by AICAR. HPAECs were stimulated for 5 to 120 minutes with 1 mmol/L AICAR. C: HPAECs were pretreated with 1 mmol/L AICAR for 30 minutes and then treated with LPS for 1 or 6 hours. Data are expressed as means ± SEM. n = 3 per group. *P < 0.05 versus control; †P < 0.05 versus LPS group. Blots are representative of three independent experiments.