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. 2013 Jan 15;21(3):602–609. doi: 10.1038/mt.2012.264

Figure 1.

Figure 1

APOB gene structure with normal and exon-skipped protein isoforms. Exons 26–29 at the 3′ end of the APOB gene are shown with the respective introns represented by connecting lines. The constitutively expressed APOB100 isoform is translated from the APOB100 mRNA, which includes the 115 nt exon 27 (top). The shorter APOB48 isoform found in the intestine is translated from the APOB100 mRNA after RNA editing of a CAA to a UAA stop codon (marker in exon 26). Exclusion of exon 27 by exon skipping leads to the APOB87 mRNA with frame-shifted exon 28 and 29 sequences and a premature stop codon (marker in exon 28). Thus, a truncated APOB protein, APOB87, is translated. Exon 27 skipping does not interfere with the exon 26 sequence, so APOB48 RNA editing and expression can proceed as normal whether or not exon 27 is skipped.