FIG. 6.

The networks wherein various signaling pathways epigenetically affected by MXC exposure intersect and the relationships between affected molecules. Molecules are represented as nodes, and the biological relationship between two nodes is represented as an edge (line). All the edges are supported by at least one reference from the literature or from canonical information stored in the Ingenuity Pathways Knowledge Base. Human, mouse, and rat orthologs of a gene are stored as separate objects in the Ingenuity Pathways Knowledge Base but are represented as a single node in the network. Nodes are displayed using various shapes that represent the functional class of the gene product. CP = canonical signaling pathway.