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. 2013 Mar 5;8(3):e55534. doi: 10.1371/journal.pone.0055534

Table 1. Comparison between multiparameter flow cytometry (MFC) and histopathology plus immunohistochemistry (IH) as regards identification of infiltration by neoplastic cells versus normal/reactive cells.

Diagnostic category N. of concordant samples by MFC vs. IH/Total samples (%)
Non-infiltrated samples: 17/17 100
Reactive/inflammatory samples 9/9 100
Other non-infiltrated samples 8/8 100
Infiltrated samples: 33/35 94
Lymphomas: 7/9 78
T-cell precursor LL 2/2 100
B-cell precursor LL 2/2 100
Diffuse large B cell lymphoma 1/1 100
Burkitt lymphoma 2/2 100
Hodgkin lymphoma 0/1 0
Anaplastic lymphoma 0/1 0
Solid Tumors: 26/26 100
Neuroblastoma 12/12 100
- Gaglioneuroblastoma 1/1 100
Rhabdomyosarcoma 4/4 100
Ewing Sarcoma/PNET 2/2 100
Adrenal carcinoma 1/1 100
Nasopharyngeal carcinoma 1/1 100
Hemagiopericytoma 1/1 100
Germ cell tumor 3/3 100
Wilmstumor 2/2 100
Total 50/52 96

All 8 samples were obtained from pediatric cancer patients, but they were all negative for the presence of tumor cells by conventional diagnostic approaches. LL: lymphoblastic lymphoma; PNET- primitive neuroectodermal tumor.