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. 2013 Mar 5;8(3):e56929. doi: 10.1371/journal.pone.0056929

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© 2013 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) SPLUNC1 and the BPI domain-deleted mutant, ΔSPLUNC1, increased the expression of the proapoptotic proteins BAX, BAD caspase-3 and 8, and decreased the antiapoptotic protein Bcl-2 expression. (B) Enforced expression of SPLUNC1 and ΔSPLUNC1 in HNE-2 cells increased cellular apoptosis.