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. 2013 Mar 5;8(3):e56929. doi: 10.1371/journal.pone.0056929

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© 2013 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) SPLUNC1 expression was significantly decreased in NP-69 cells transfected with LMP1. (B) miR-141 expression was significantly increased in NP-69 cells transfected with LMP1. (C) PTEN expression was decreased and the Akt pathway was activated by foreign LMP1 expression. (D) Re-expression of SPLUNC1 in LMP1-transfected cells led to inhibition of LMP1 expression and induction of PTEN.