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. 2013 Mar 5;8(3):e57973. doi: 10.1371/journal.pone.0057973

Figure 3. Comparison of AHR pathway gene expression in livers with a shunt and normal livers.

Figure 3

The pattern of expression of selected genes in liver samples from Irish wolfhounds with an intrahepatic shunt (Iw), dogs with intrahepatic portosystemic shunts (IHPSS), and healthy dogs (H). The thick black line represents the median (50th percentile); the first and third quartile (25th and 75th percentile, respectively) are displayed. Outliers are depicted with an open dot, representing values higher than 1.5 times the interquartile range. HIF1A was found to be significantly upregulated in Irish wolfhounds with IHPSS, whereas AHR, AIP, ARNT2, CYP1A2, CYP1B1, HSP90AA1, NOS3, and VEGFA were significantly down regulated. No differences were observed in ARNT, CYP1A1, and EDN1. FC = fold change.