Table 4. Frequencies of MTHFR C677T genotypes and alleles by gendera.
| Gender | Number of subjects | MTHFR C677T genotype, n (%) | Allele frequency | |||||
| CC | CT | TT | 95%CI | C | T | 95%CI | ||
| Malesb | 952 | 208 (21.9) | 465 (48.8) | 279 (29.3) | (26.4–32.3) | 46.3 | 53.7 | (51.5–56.0) |
| Females | 932 | 199 (21.4) | 450 (48.3) | 283 (30.4) | (27.4–33.4) | 45.5 | 54.5 | (52.2–56.8) |
| Total | 1884 | 407 (21.6) | 915 (48.6) | 562 (29.8) | (27.8–32.0) | 45.9 | 54.1 | (52.5–55.7) |
Abbreviations: MTHFR, methylenetetrahydrofolate reductase; CC, “wild-type” homozygosity; CT, heterozygosity; TT, mutant homozygosity; CI, confidence interval.
a
All participants were from Tianjin municipality.
b
The 677T allele and the 677TT genotype frequencies were not significantly different from females (χ2 = 0.23, P = 0.6321 and χ2 = 0.26, P = 0.6157, respectively).