Table 1. Localization of SIV infected cells in LN from SM and PM.

	SIV Productively Infected Cells
	Paracortex			Germinal Center
	SM	CD8-depleted SM	PM	SM	CD8-depleted SM	PM
Wk2	+++	++++	+++	− (n = 24)	+* (n = 15)	++ (n = 42)
Wk 5/6	+	+	+++	− (n = 80)	+* (n = 43)	+++ (n = 56)
Wk21/24	+	+	++	− (n = 54)	+* (n = 23)	++ (n = 80)

Infected cells, as quantified by ISH for SIV RNA. Histomorphological localization of infected cells (identified by dark blue NBT/BCIP chromogen) in GC versus paracortical microenvironments was accomplished by microscopic analysis of Nuclear Fast Red counterstain. Scoring is based on the average for each group at each time point, divided into quartiles (+; 0–5/mm²) (++; 6–15/mm²); (+++; 16–50/mm²); (++++; >50/mm²) derived from quantitative measurements. Asterisk (*) Indicates one germinal center contained an SIV-infected cell at 2, 6, and 24 wpi in a CD8 depleted SM. Numbers of GC evaluated at each time-point is indicated by n values.