Table 4. Association of genes with overall survival in K2 and TCGA series.
K2 Series–Czech Republic | TCGA Series–US | |||||||||||
Univariate Analysis | Multivariate Analysis* | Univariate Analysis | Multivariate Analysis* | |||||||||
Gene | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value |
CLEC14A | 0.26 | 0.14–0.52 | <0.001 | 0.41 | 0.19–0.9 | 0.025 | 0.72 | 0.64–0.81 | <0.001 | 0.81 | 0.71–0.93 | 0.002 |
CLEC1A | 0.08 | 0.02–0.29 | <0.001 | 0.19 | 0.04–0.9 | 0.037 | 0.72 | 0.61–0.84 | <0.001 | 0.83 | 0.69–1 | 0.049 |
CYYR1 | 0.18 | 0.08–0.39 | <0.001 | 0.29 | 0.1–0.79 | 0.015 | 0.68 | 0.6–0.77 | <0.001 | 0.79 | 0.69–0.91 | 0.001 |
EFNB2 | 0.19 | 0.08–0.43 | <0.001 | 0.34 | 0.13–0.92 | 0.034 | 0.70 | 0.61–0.8 | <0.001 | 0.81 | 0.69–0.95 | 0.008 |
GPR116 | 0.17 | 0.07–0.39 | <0.001 | 0.30 | 0.11–0.8 | 0.016 | 0.69 | 0.61–0.78 | <0.001 | 0.81 | 0.7–0.93 | 0.004 |
LDB2 | 0.24 | 0.13–0.46 | <0.001 | 0.36 | 0.16–0.8 | 0.013 | 0.71 | 0.63–0.8 | <0.001 | 0.82 | 0.71–0.95 | 0.009 |
S1PR1 | 0.07 | 0.02–0.27 | <0.001 | 0.16 | 0.04–0.69 | 0.014 | 0.68 | 0.61–0.77 | <0.001 | 0.79 | 0.69–0.9 | <0.001 |
TMEM204 | 0.17 | 0.07–0.38 | <0.001 | 0.31 | 0.11–0.85 | 0.023 | 0.74 | 0.65–0.84 | <0.001 | 0.84 | 0.72–0.98 | 0.025 |
Results from univariate and multivariate Cox’s proportional hazard model analysis of prognostic factors for overall survival in K2 (expression microarrays) and TCGA (RNA-Seq) populations for a selection of genes. Abbreviations used: HR – hazard ratio; CI – confidence interval.
Adjusted for age (continuous), grade, pT, sex.