Table 4. Association of genes with overall survival in K2 and TCGA series.

	K2 Series–Czech Republic						TCGA Series–US
	Univariate Analysis			Multivariate Analysis*			Univariate Analysis			Multivariate Analysis*
Gene	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
CLEC14A	0.26	0.14–0.52	<0.001	0.41	0.19–0.9	0.025	0.72	0.64–0.81	<0.001	0.81	0.71–0.93	0.002
CLEC1A	0.08	0.02–0.29	<0.001	0.19	0.04–0.9	0.037	0.72	0.61–0.84	<0.001	0.83	0.69–1	0.049
CYYR1	0.18	0.08–0.39	<0.001	0.29	0.1–0.79	0.015	0.68	0.6–0.77	<0.001	0.79	0.69–0.91	0.001
EFNB2	0.19	0.08–0.43	<0.001	0.34	0.13–0.92	0.034	0.70	0.61–0.8	<0.001	0.81	0.69–0.95	0.008
GPR116	0.17	0.07–0.39	<0.001	0.30	0.11–0.8	0.016	0.69	0.61–0.78	<0.001	0.81	0.7–0.93	0.004
LDB2	0.24	0.13–0.46	<0.001	0.36	0.16–0.8	0.013	0.71	0.63–0.8	<0.001	0.82	0.71–0.95	0.009
S1PR1	0.07	0.02–0.27	<0.001	0.16	0.04–0.69	0.014	0.68	0.61–0.77	<0.001	0.79	0.69–0.9	<0.001
TMEM204	0.17	0.07–0.38	<0.001	0.31	0.11–0.85	0.023	0.74	0.65–0.84	<0.001	0.84	0.72–0.98	0.025

Results from univariate and multivariate Cox’s proportional hazard model analysis of prognostic factors for overall survival in K2 (expression microarrays) and TCGA (RNA-Seq) populations for a selection of genes. Abbreviations used: HR – hazard ratio; CI – confidence interval.

^*Adjusted for age (continuous), grade, pT, sex.