Table 1.
Characteristics of Cryotherapy Subjects, Topical Minocycline Subjects, and Comparison Subjects (N = 206)
| Cryotherapy Subjects (n = 51) |
Minocycline Subjects (n = 63) |
Comparison Subjects (n = 92) |
P Value | |
|---|---|---|---|---|
| Gender [n (%)] | .25 | |||
| M | 27 (47) | 25 (40) | 36 (39) | |
| F | 24 (53) | 38 (60) | 56 (61) | |
| Race [n (%)]* | .70 | |||
| White | 38 (75) | 55 (87) | 71 (79) | |
| African American | 4 (8) | 2 (3) | 10 (11) | |
| Other | 9 (17) | 6 (10) | 9 (10) | |
| Bone removal from both mandibular third molars [n (%)]† | 33 (65) | 42 (62) | 76 (83) | .08 |
| Mandibular occlusal plane position [n (%)] | .04 | |||
| Third molars at plane | 28 (62) | 22 (37) | 39 (52) | |
| Third molars below plane | 17 (38) | 37 (63) | 36 (48) | |
| Age at surgery [median (IQR)] (yr) | 21 (19–24) | 21 (19–23) | 20 (18–24) | .15 |
| Total surgery time [median (IQR)] (min) | 25 (20–40) | 27 (20–40) | 25 (18–30) | .03 |
| Surgeon’s assessment of degree of difficulty (4–28 possible) [median (IQR)] | 14 (11–17) | 14 (10–18) | 12 (9–16) | .09 |
NOTE. Cryotherapy subjects were included from 2005 to 2009 from 1 academic center. Topical minocycline subjects were included from 2003 to 2004 from 2 academic centers and 2 community practices. Comparison subjects were included from 2002 to 2006 from 3 academic centers and 2 community practices. Differences between comparison and treatment groups for demographic characteristics and extensiveness of surgery were assessed with χ2 or Cochran-Mantel-Haenszel row mean score tests. The level of significance was set at P < .05.
Abbreviation: IQR, interquartile range.
Missing 2 subjects in comparison group.
Missing 5 subjects in minocycline group.
Gelesko et al. Cryotherapy/Minocycline for Pain Control. J Oral Maxillofac Surg 2011.