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. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Cell Metab. 2013 Feb 5;17(2):197–209. doi: 10.1016/j.cmet.2013.01.009

Fig. 1. Skeletal muscle insulin resistance in LRP6R611C mutation carriers.

Fig. 1

LRP6R611C mutation carriers (R611C), with or without impaired glucose tolerance (IGT and NGT), had higher circulating glucose levels in response to oral glucose load compared to non-carrier relatives (WT) (A). Serum insulin levels were higher in LRP6R611C mutation carriers compared to non-carrier relatives during the last stages of the OGTT (B). The insulin sensitivity index (ISI) was significantly lower in LRP6R611C mutation carriers with NGT compared to non-carriers (C). IR mRNA expressions (D), IR protein levels and AKT phosphorylation (E) were significantly lower in mutation carriers with NGT (lanes3–4) and DM2 (lanes 5–6) compared to non-carriers (lanes1–2). Fig. 1F and G show quantification of IR and pAKT by densitometry (* specifies p<0.05, ** p<0.005). Error bars represent standard deviation (SD).