Table 2.

Demographic subject data for experiments that were analyzed longitudinally before and after cognitive decline in the same subject. Cognitive Development: subjects marked as “decline” deteriorated cognitively over the time span indicated under Δ Time, while “stable” subjects did not change cognitively over the same time span (MCI => MCI). Sampling date: a = first serum collection, b = second serum collection. Δ Time: average time between first and second serum collection in the same subject. Errors represent SD. Differences in Age and Δ Time were evaluated using the Mann-Whitney non-parametric test. No significant differences between sample sets were found

Experiment	Cognitive development	Sampling date	n (female/male)	Age [years]	Δ Time [years]
Mass Spectrometry: analysis by disease progression	decline	a	3 (2/1)	79.0 ± 2.7
		b	3 (2/1)	80.0 ± 2.7	1 ± 0.0
Reverse Phase Protein Array: analysis by disease progression	stable	a	6 (4/2)	80.5 ± 5.6
		b	6 (4/2)	81.8 ± 5.7	1.5 ± 0.5
	decline	a	6 (4/2)	80.2 ± 7.2
		b	6 (4/2)	82.0 ± 6.9	1.8 ± 0.4