Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Mar;23(3):555–567. doi: 10.1101/gr.147942.112

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported License), as described at http://creativecommons.org/licenses/by-nc/3.0/.

PMC Copyright notice

Figure 4. — Correlation between CpG methylation and gene expression depends on genomic context. (A,B) CpGs <2000 bp away from the transcription start site (TSS) are negatively correlated with expression, regardless of whether they reside in a CpG island. (C) CpGs that are in gene bodies far from the TSS (>2000 bp away) and reside in CpG islands can be either positively or negatively correlated with gene expression. (D) CpGs that are in the gene body far from the TSS (>2000 bp away) and do not reside in CpG islands and are positively correlated with gene expression. (E) Model of relationship between methylation and gene expression. Expressed genes are associated with unmethylated promoters, methylated gene bodies, and unmethylated intragenic CpG island EP300-bound enhancers. (F) Silenced genes are associated with methylated promoters, unmethylated gene bodies, and methylated intragenic CpG island enhancer elements.