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. 2013 Feb 15;27(4):372–377. doi: 10.1101/gad.207001.112

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Figure 5. — Haploinsufficiency of p53 rescues apoptosis and allows for cell survival during differentiation in DNMT1^PCp53^+/− pancreas. (A,B) Immunohistochemical staining for Sox9 and Pdx indicates no significant difference in the control (A) and DNMT1^PCp53^+/− (B) cell populations at E15.5. (C,D) Immunohistochemical analysis of control (C) and DNMT1^PCp53^+/−yfp⁺ (D) pancreas revealed a restoration of Ngn3⁺ expression in the absence of Dnmt1. Overlap with YFP indicates that these cells have arisen from cells that underwent recombination. (E,F) Gross analysis of control and DNMT1^PCp53^+/−yfp⁺ indicates that mutant pancreas are comparable with control littermates at P0. (G,H) Lineage tracing by YFP expression indicates that most cells in the DNMT1^PCp53^+/−yfp⁺ pancreas have undergone recombination.