Figure 6.

GHR gene disruption in adipose tissue does not alter RNA levels encoding intracellular signaling molecules that are known to affect glucose metabolism in WAT. Retroperitoneal WAT from female FaGHRKO mice was collected at 8 months of age. Relative mRNA levels of PGC1α, SIRT1, PPARα, PPARδ, PPARγ, 4-1BB, SREBP, FAS, and GLUT4, are shown for FaGHRKO (FFCx; black bars) and controls (FFxx; white bars). Values are presented relative to control values ± SEM (n = 6–7 per group). FaGHRKO (FFCx) vs control (FFxx).