Table 2.
IGF-1 and IGFBP Levels of FaGHRKO and Control Male and Female Mice
| Fat GHR−/− (Male) |
Fat GHR−/− (Female) |
|||||
|---|---|---|---|---|---|---|
| FFxx | FFCx | P Value | FFxx | FFCx | P Value | |
| GH and IGF-1 | ||||||
| GH, n = 9–10 (ng/ml) | 7.9 ± 3.2 | 12.1 ± 4.5 | .466 | 7.6 ± 1.6 | 7.9 ± 2.1 | .915 |
| IGF-1, n = 9–10 (ng/ml) | 503 ± 19 | 613 ± 30a | .006 | 655 ± 31 | 705 ± 32 | .275 |
| IGFBPs | ||||||
| IGFBP-1, n = 9–10 (pg/ml) | 7.4 ± 2.0 | 11 ± 1.7 | .147 | 22 ± 6.4 | 38 ± 13 | .285 |
| IGFBP-2, n = 9–10 (pg/ml) | 160 ± 8.5 | 172 ± 8.0 | .329 | 199 ± 10 | 204 ± 16 | .789 |
| IGFBP-3, n = 9–10 (pg/ml) | 189 ± 19 | 229 ± 14 | .109 | 248 ± 13 | 241 ± 11 | .711 |
| IGFBP-5, n = 9–10 (pg/ml) | 5.8 ± 0.3 | 7 ± 0.5 | .062 | 7 ± 0.4 | 9 ± 0.8a | .033 |
| IGFBP-6, n = 9–10 (pg/ml) | 133 ± 12 | 142 ± 11 | .586 | 155 ± 8.8 | 134 ± 14 | .228 |
| IGFBP-7, n = 9–10 (pg/ml) | 13 ± 1.0 | 13 ± 1.2 | .850 | 13 ± 1.4 | 15 ± 1.5 | .428 |
Abbreviations: FFxx, controls; FFCx, FaGHRKO. Circulating peptide values of male and female mice at 6 months of age. Values are represented as mean ± SEM (n = 9–10 per group).
a
Significance with P values given to the right.